The title "Hermes de Fonseca, Rio de Janeiro, EPUC 1994" immediately raises questions. A search for this specific publication, purportedly focusing on pharmacological principles and drug interactions, yields no readily available results. The provided metadata – referencing a 1991 publication on drug interactions from EPUC (Escola Politécnica da Universidade Católica, likely in Rio de Janeiro) and associating it with a 2013 entry linked to Hermes da Fonseca – points to a significant discrepancy. This article will explore the potential reasons for this lack of readily available information, examine the broader context of drug interaction studies in the early to mid-1990s, and consider the possible misattribution or confusion surrounding the supposed 1994 publication.
The metadata suggests a possible connection between a 1991 work on drug interactions (likely the "(PDF) Interações medicamentosas: fundamentos para a pratica ;Rio de Janeiro; EPUC; 1991. 440 p.") and a later work, possibly a revised edition or a related publication by Hermes da Fonseca in 1994. However, the absence of readily accessible information regarding this 1994 publication raises several possibilities:
* Publication Error/Misattribution: The 1994 date may be incorrect. It's possible that the information concerning the 1994 publication is a typographical error, a misremembering, or a misattribution to Hermes da Fonseca. The 1991 publication from EPUC might be the correct source, and the 1994 date is a mistake.
* Limited Circulation/Internal Publication: The 1994 publication might have been a limited-circulation document, perhaps an internal report or a thesis, not widely distributed or indexed in standard academic databases. Such publications are often difficult to access outside of specific institutional archives.
* Unpublished Work: The publication may never have been formally published. It could have been a planned work that never progressed beyond the drafting stage.
* Name Confusion: There might be confusion surrounding the author's name or the institution involved. A slight variation in spelling or an incomplete name could lead to difficulty in locating the publication.
Given the lack of readily available information, focusing on the broader context of drug interaction research during the relevant period provides valuable insight. The early to mid-1990s saw significant advancements in our understanding of pharmacokinetics and pharmacodynamics, leading to a growing awareness of the complexities of drug interactions. The development of more sophisticated analytical techniques allowed researchers to better identify and quantify drug-drug interactions.
A 1991 publication on drug interactions, such as the one mentioned, would likely have covered the following fundamental areas:
* Pharmacokinetic Interactions: These interactions affect the absorption, distribution, metabolism, and excretion (ADME) of drugs. A book from this period would likely discuss factors such as altered bioavailability due to changes in gastrointestinal pH, competition for binding sites on plasma proteins, enzyme induction or inhibition affecting drug metabolism (particularly cytochrome P450 enzymes), and the influence of renal function on drug excretion.
* Pharmacodynamic Interactions: These interactions involve the effects of drugs on the body's physiological responses. The book would likely explain additive, synergistic, or antagonistic effects, including interactions at receptor sites, alterations in neurotransmitter release, and effects on physiological pathways.
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